The Fixation of Complement and the Activated First Component (c1) of Complement by Complexes Formed between Antibody and Divalent Hapten

The interaction of protein A and Fc fragment of rabbit immunoglobulin G as probed by complement-fixation and nuclear-magnetic-resonance studies.

Protein-A-Fc-fragment complexes were observed in sedimentation-velocity experiments by ultracentrifugation. The interaction was studied by protein-fluorescence-quenching titrations of the Fc fragment with protein A, allowing the dissociation constant to be determined under a variety of conditions. The first component of the complement pathway, C1, is activated by complexes of protein A with rab...

Vertex Decomposable Simplicial Complexes Associated to Path Graphs

Introduction Vertex decomposability of a simplicial complex is a combinatorial topological concept which is related to the algebraic properties of the Stanley-Reisner ring of the simplicial complex. This notion was first defined by Provan and Billera in 1980 for k-decomposable pure complexes which is known as vertex decomposable when . Later Bjorner and Wachs extended this concept to non-pure ...

The Role of Immunological Factors on Sudden Sensoryneural Hearing Loss

Introduction: In this study, we examined the role of immunological factors on sudden sensory neural hearing loss (SSNHL).   Materials and Methods: This prospective case-controlled study was performed in patients with SSNHL who referred to the ear, nose, and throat (ENT) ward. Fifty-six patients with SSNHLoccurring within a 72-hr period were selected as the case group and 56 participants who ha...

Detection of rotavirus by Latex Agglutination Test (Rotales); Comparison with Electron Microscopy and Complement Fixation Test

Complement activation by a univalent hapten-antibody complex.

The univalent hapten, nonadeca lysyl epsilon-Dnp-lysine, binds tightly to rabbit anti-2,4-dinitrophenyl antibody, and the complex has a sedimentation coefficient of 6.7, characteristic of a single antibody molecule. In this communication, we show that this complex is a good activator of the serum complement system. For activation to occur, the univalent hapten must contain the specific group wh...